Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 84, Issue 12, Pages 2380-2385Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2015.03.022
Keywords
Perfusion CT; Cancer; Treatment response
Funding
- National Institute for Health Research via the Health Technology Assessment Programme
- Department of Health via the National Institute for Health Research Comprehensive Biomedical Research Centre
- King's College London
- King's College Hospital NHS Foundation Trust
- King's College London/University College London Comprehensive Cancer Imaging Centre - Cancer Research UK
- Engineering and Physical Sciences Research Council
- Medical Research Council
- Department of Health
- Cancer Research UK [16463] Funding Source: researchfish
- National Institute for Health Research [09/22/49] Funding Source: researchfish
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Perfusion CT was first described in the 1970s but has become accepted as a clinical technique in recent years. In oncological practice Perfusion CT allows the downstream effects of therapies on the tumour vasculature to be monitored. From the dynamic changes in tumour and vascular enhancement following intravenous iodinated contrast agent administration, qualitative and quantitative parameters may be derived that reflect tumour perfusion, blood volume, and microcirculatory changes with treatment. This review outlines the mechanisms of action of available therapies and state-of-the-art imaging practice. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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