Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 33, Pages 6752-6761Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb01233k
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Funding
- National Natural Science Foundation of China [21571105, 21671105]
- program of natural science research of Jiangsu higher education institutions of china [15KJB150013]
- NSF of Jiangsu Province of China [BK20161554]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Foundation of Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials [161090H001]
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Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species (ROSs) to kill cancer cells. However, a high concentration of reduced glutathione (GSH) is present in cancer cells and can consume ROSs and sharply reduce the PDT activity. To address this problem, herein, we synthesized a thymine modified Zn phthalocyanine (ZnPc, a monomer and an active form for PDT) and prepared its nanoparticle form (an aggregator and an inactive form) with Hg2+ providing the driving force for the thymine-Hg2+-thymine'' interaction. The nanoparticles could remain in the inactive form during the delivery process in blood. Once endocytosed by cancer cells, the nanoparticles are disintegrated, and deprived of Hg2+ by intracellular GSH, which decreases the level of GSH. Simultaneously, the activity of the released monomer ZnPc is recovered and high PDT activity is observed.
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