Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 9, Pages 1856-1862Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb03215j
Keywords
-
Categories
Funding
- National Basic Research Program of China (973 Program) [2014CC339900]
- National Nature Science Foundation of China [61605014, 61575017, 61401031]
- Chinese Postdoctoral Science Foundation [2016M591126]
Ask authors/readers for more resources
A type of polymeric nanoparticles loading indocyanine green and Pt(II)-porphyrins (ICG-Pt-NPs) is constructed to achieve a synergistic effect of combined photothermal and two-photon activated photodynamic therapy. The nanoparticle core comprises the photosensitizer Pt(II)-porphyrins (PtTFPP), and organic semiconducting polymer (PFO) that acts as a two-photon antenna. Negative ICG molecules, an NIR-absorbing photothermal dye, can be loaded into the positively charged poly-L-lysine (PLL) shell of the polymeric nanoparticles via electrostatic interaction. In these carefully designed ICG-PtTFPP integrated nanoparticles, PtTFPP absorbs the photonic energy transferred by the PFO polymer under two-photon laser excitation at 740 nm to induce photodynamic cancer cell death, while ICG offers nanoparticles a strong photothermal performance under 808 nm laser irradiation. Compared with photodynamic therapy or photothermal therapy alone, the combined therapy had a significantly synergistic effect and improved the therapeutic efficacy with near-infrared irradiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available