Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 11, Pages 2086-2095Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb00224f
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Funding
- National Natural Science Foundation of China (NSFC) [51332008, 51372243, 51422209, 51628201, 21401032, 51502050]
- National Basic Research Program of China [2014CB643803]
- science and technology development plan of Jilin Province [20170414003GH]
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The design of stimuli-responsive drug delivery systems has attracted much attention to improve therapeutic efficacy for clinical applications. Here an 808 nm NIR light responsive dual-drug system was designed for cancer treatment both in vitro and in vivo. Mesoporous silica coated NaYF4: Yb-0.4/Tm-0.02@NaGdF4: Yb-0.1@NaNdF4:Yb-0.1 (UCNPs) with a core-shell structure (labeled as UCNPs@mSiO(2)) was prepared and loaded with the antitumor drug doxorubicin (DOX). The surface of the composite was functionalized with beta-cyclodextrin rings bridged by the light cleavable platinum(IV) pro-drug, thus blocking DOX inside the mesopores of silica. When excited by 808 nm NIR light, the emitted UV light from the UCNPs was used to activate the platinum(IV) pro-drug to gain higher toxicity platinum(II) complexes and open the mesopores of silica (at the same time) to release DOX molecules. Both DOX and platinum(II) complexes can kill cancer cells. This dual-drug delivery system may represent a new avenue for the application of UCNPs in photoactivated cancer therapy.
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