Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 3, Pages 401-417Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb02308h
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Funding
- National Natural Science Foundation of China [81571742, 81371618, 51373117, 51573128, 81271630, 81601603]
- Shanghai Innovation Program [14ZZ039]
- Key Project of Tianjin Natural Science Foundation [13JCZDJC33200]
- National High Technology Program of China [2012AA022603]
- Doctoral Base Foundation of Educational Ministry of China [20120032110027]
- Program for Outstanding Young Teachers in Tongji University
- Fundamental Research Funds for the Central Universities
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Currently, protein/peptide-based biomimetic mineralization has been demonstrated to be an efficient and promising strategy for synthesis of inorganic/metal nanoparticles (NPs) for bioapplications. This strategy is found to be bio-inspired, straightforward, and environmentally benign. It can produce inorganic/metal NPs with good stability, excellent biocompatibility, high water solubility, and rich surface functional groups for further bioconjunction. In this review, we provide a summary of the previously reported proteins/peptides as biotemplates involved in biomimetic mineralization synthesis, and categorize the obtained inorganic NPs ranging from metal nanoclusters (MNCs), quantum dots (QDs), gadolinium derivatives, and metal sulfide nanoparticles (MSNPs) with an emphasis on the recent progress in their use in biomedical applications, including bio-sensing, ion detection, bio-labeling, in vivo imaging and therapy. In the end, the challenges and future outlook in this emerging area are also discussed.
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