Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 84, Issue 9, Pages 1650-1657Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2015.05.013
Keywords
Contrast enhanced ultrasound; Therapy assessment; Anti-angiogenic therapy Cancer; Anti-inflammatory therapy; Inflammatory bowel disease
Funding
- Canadian Institutes of Health Research [MOP 126157]
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Quantitative imaging is a crucial component of the assessment of therapies that target the vasculature of angiogenic or inflamed tissue. Dynamic contrast-enhanced ultrasound (DCE-US) using microbubble contrast offers the advantages of being sensitive to perfusion, non-invasive, cost effective and well suited to repeated use at the bedside. Uniquely, it employs an agent that is truly intravascular. This papers reviews the principles and methodology of DCE-US, especially as applied to anti-angiogenic cancer therapies. Reproducibility is an important attribute of such a monitoring method: results are discussed. More recent technical advances in parametric and 3D DCE-US imaging are also summarised and illustrated. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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