Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 35, Pages 7267-7273Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb01588g
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Funding
- Science and Technology Commission of Shanghai Municipality [17540712000]
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [81761148028, 21773026, 51602334, 81671740]
- National Key Research and Development Program of China [2016YFC0107108]
- Shanghai Academic/Technology Research Leader Program [17XD1424200]
- FCT-Foundation for Science and Technology [PEst-OE/QUI/UI0674/2013]
- Madeira Chemistry Center - CQM + (Madeira 14-20) [M1420-01-0145-FEDER-000005]
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We report a convenient strategy to prepare ultrasmall Fe3O4 nanoparticles (NPs) coated with zwitterion L-cysteine (Cys) for enhanced T-1-weighted magnetic resonance (MR) imaging applications. The formed Fe3O4-PEG-Cys NPs possess antifouling properties, good r(1) relaxivity, excellent cytocompatibility and hemocompatibility, and can be used as a contrast agent for enhanced blood pool and tumor MR imaging.
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