Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 43, Pages 8600-8606Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb01680h
Keywords
-
Categories
Funding
- National Nature Science Foundation of China [21171001, 51372004, 21571002, 21371003]
- Anhui Province Key Laboratory of Environment-Friendly Polymer Materials
- Project of the Natural Science Foundation of Anhui Provincial Education Department [KJHS2016B05]
Ask authors/readers for more resources
A novel litchi-like porous composite composed of a magnetic core, a tunable metal-organic framework (MOF) shell and a pH-sensitive hydroxyapatite (HAp) gatekeeper was successfully fabricated in this work. The anticancer drug doxorubicin (DOX) was effectively loaded on the Fe3O4@Fe-MOF@HAp nanocomposite with a loading capacity of 75.38 mg g(-1). The nanocomposite had a saturation magnetization of 34 emu g(-1) and thus possessed magnetic targeting function. In addition, the HAp gate, which had favorable biocompatibility and pH response characteristics, could be used to control the release of loaded DOX from the Fe3O4@Fe-MOF@HAp nanocomposite microspheres in a simulated acidic tumor cell environment, effectively killing tumor cells and reducing the toxic side effects to normal tissue. The smart design presented in this study, which incorporates a tunable shell and gate-controlled architecture, allows the sensitive release of drugs for efficient antitumor activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available