Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 36, Pages 7547-7556Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb02002c
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Funding
- Regione Puglia
- Costituzione di Reti di Laboratori Pubblici di Ricerca
- Progetto Esecutivo [09]
- WAFITECH
- FutureInResearch'' APQ Ricerca Regione Puglia and Sistema Puglia
- Ricerca e Innovazione Tecnologica
- Politiche per lo Sviluppo
- Cluster Tecnologici Sviluppo di nuove metodologie e strumenti Innovativi per la diagnoSi ed il trattamento Terapeutico di tumori Epiteliali uMAni (SISTEMA)'' [T7WGSJ3]
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Superparamagnetic magnetite nanoparticles were synthetized and capped by a SiO2 shell in order to avoid oxidation and aggregation of the iron oxide nanostructures. The inorganic capping was then further decorated by folic acid molecules, by using a very simple procedure exploiting supramolecular interactions among the organic moieties and the inorganic nanoparticles. The supramolecular nanoadduct thanks to folic acid molecules could act as a Trojan horse'' for the cancer cells and due to its superparamagnetic properties could induce local heat generation upon an appropriate magnetic field application. In fact, temperature was increased up to 42 degrees C when a 18 mT magnetic field was applied to the nanoparticles and the hybrid nanostructures were verified to be selectively internalized by HeLa cells, a human cervical cancer line known to overexpress the folic acid receptor.
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