Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 34, Pages 7008-7013Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb01217a
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Funding
- National Science Council of Taiwan [101-2628-E-002-015-MY3, 101-2623-E-002-005-ET, 101-2923-E-002-012-MY3]
- National Taiwan University [102R7842, 102R7740, 102R104100]
- Chang Gung Memorial Hospital [CMRPD2C0071-73]
- National Health Research Institute (NHRI) of Taiwan [03A1-BNMP14-014, NHRI-EX106-10311EC]
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Herein, pilocarpine-loaded gelatin-covered mesoporous silica nanoparticles (denoted as p/GM) were intracamerally administrated into the anterior chamber for the reduction of intraocular pressure (IOP). The in vitro release profile shows that p/GM demostrates a high release percentage (50%) with a long-lasting release profile (36 days). The in vivo studies showed the maintenance of IOP in eye with ocular hypertension for 21 days.
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