4.6 Article

In vivo self-assembly induced retention of gold nanoparticles for enhanced photothermal tumor treatment

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 30, Pages 5931-5936

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb01268c

Keywords

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Funding

  1. National Natural Science Foundation of China for Innovative Research Groups [51621002]
  2. National Key Research and Development Program of China [2016YFA0203700]
  3. NSFC [51572083, 51461165202, 51472085]
  4. Shanghai Rising-Star Program [16QA1401300]
  5. Shanghai Chenguang Project [13CG25]
  6. 111 project [B14018]
  7. Fundamental Research Funds for the Central Universities

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We present a simple route to fabricate peptide modified spherical gold nanoparticles (AuNPs@Pep1/Pep2) with enhanced retention performance in tumor sites for improved photothermal treatment (PTT), which was achieved through its in vivo self-assembly triggered by matrix metalloproteinase-2 (MMP-2).

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