4.6 Article

Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 6, Pages 1143-1147

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb02773c

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Funding

  1. European Union's Seventh Framework Programme [604434]
  2. Departamento de Desarrollo Economico y Competitividad of the Basque Government [KK-2015/0000088]
  3. Spanish Ministry of Economy and Competitiveness [MAT2013-48169-R]

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Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and under mild conditions. Radiolabeling of the resulting biocompatible materials allowed the study of lung deposition of aqueous aerosols after intratracheal nebulization by means of single-photon emission computed tomography (SPECT), demonstrating their potential use as imaging contrast agents.

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