Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 5, Issue 21, Pages 3898-3906Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb02576e
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Funding
- Science and Technology Commission of Shanghai [15JC1491001]
- National Natural Science Foundation of China [51472259]
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In this work, a novel ultralong hydroxyapatite microtube (HMT)-chitosan (CHS) composite scaffold has been successfully prepared. The mechanical properties of the HMT-CHS composite scaffold is greatly improved compared with the CHS-hydroxyapatite nanorod scaffold and the pure chitosan scaffold. By using gentamicin sulfate (GS) as the model drug, the GS-loaded HMT-CHS composite scaffold has a high drug loading capacity, sustained drug release behavior and high antibacterial activity. The as-prepared HMT-CHS composite scaffold has promising applications in various fields such as drug delivery and bone defect repair.
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