Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 84, Issue 2, Pages 312-317Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2014.11.006
Keywords
Lung carcinoma; Support vector machine; F-18-FDG; PET-CT
Funding
- National Natural Science Fund of China [81171405]
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Objective: In clinical practice, image analysis is dependent on simply visual perception and the diagnostic efficacy of this analysis pattern is limited for mediastinal lymph nodes in patients with lung cancer. In order to improve diagnostic efficacy, we developed a new computer-based algorithm and tested its diagnostic efficacy. Methods: 132 consecutive patients with lung cancer underwent F-18-FDG PET/CT examination before treatment. After all data were imported into the database of an on-line medical image analysis platform, the diagnostic efficacy of visual analysis was first evaluated without knowing pathological results, and the maximum short diameter and maximum standardized uptake value (SUVmax) were measured. Then lymph nodes were segmented manually. Three classifiers based on support vector machine (SVM) were constructed from CT, PET, and combined PET-CT images, respectively. The diagnostic efficacy of SVM classifiers was obtained and evaluated. Results: According to ROC curves, the areas under curves for maximum short diameter and SUVmax were 0.684 and 0.652, respectively. The areas under the ROC curve for SVM1, SVM2, and SVM3 were 0.689, 0.579, and 0.685, respectively. Conclusion: The algorithm based on SVM was potential in the diagnosis of mediastinal lymph nodes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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