Journal
BRITISH JOURNAL OF NUTRITION
Volume 117, Issue 1, Pages 93-107Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114516004037
Keywords
Probiotics; Gut microbiota; Gut barrier; Immunity; Gastrointestinal disorders
Categories
Funding
- ILSI Europe Probiotic Task Force
- FNRS
- French Cancer Research Association (ARC)
- Fonds de la Recherche Scientifique - FNRS [WELBIO-CR-2012S-02R]
- Funds InBev-Baillet Latour
- ERC Starting Grant
- European Research Council, Starting grant [336452-ENIGMO]
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Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.
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