Journal
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Volume 312, Issue 1, Pages R108-R113Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00361.2016
Keywords
cerebral blood flow; dynamic cerebral autoregulation; transfer function analysis; transcranial Doppler; autoregulation index
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Funding
- Coordenacao de Apoio ao Pessoal de Ensino Superior
- National Institute for Health Research [NF-SI-0515-10054, CL-2013-11-002] Funding Source: researchfish
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Patients with ischemic heart failure (iHF) have a high risk of neurological complications such as cognitive impairment and stroke. We hypothesized that iHF patients have a higher incidence of impaired dynamic cerebral autoregulation (dCA). Adult patients with iHF and healthy volunteers were included. Cerebral blood flow velocity (CBFV, transcranial Doppler, middle cerebral artery), end-tidal CO2 (capnography), and arterial blood pressure (Finometer) were continuously recorded supine for 5 min at rest. Autoregulation index (ARI) was estimated from the CBFV step response derived by transfer function analysis using standard template curves. Fifty-two iHF patients and 54 age-, gender-, and BP-matched healthy volunteers were studied. Echocardiogram ejection fraction was 40 (20-45) % in iHF group. iHF patients compared with control subjects had reduced end-tidal CO2 (34.1 +/- 3.7 vs. 38.3 +/- 4.0 mmHg, P < 0.001) and lower ARI values (5.1 +/- 1.6 vs. 5.9 +/- 1.0, P = 0.012). ARI <4, suggestive of impaired CA, was more common in iHF patients (28.8 vs. 7.4%, P = 0.004). These results confirm that iHF patients are more likely to have impaired dCA compared with age-matched controls. The relationship between impaired dCA and neurological complications in iHF patients deserves further investigation.
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