Journal
BIORESOURCES AND BIOPROCESSING
Volume 4, Issue -, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1186/s40643-017-0186-0
Keywords
Metal-organic frameworks; Glucose oxidase; Zeolitic imidazolate framework
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Funding
- National Natural Science Foundation of China [21336002, 21676104, 21376096]
- Fundamental Research Funds for the Chinese Universities [2015PT002, 2015ZP009]
- State Key Laboratory of Pulp and Paper Engineering [2017ZD05]
- State Key Laboratory of Bioreactor Engineering
- Foshan University [GG07016]
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( )Background: The ZIF-8-coated magnetic regenerated cellulose-coated nanoparticles (ZIF-8@cellu@Fe3O4) were successfully prepared and characterized. The result showed that ZIF-8 was successfully composited on to the surface of the cellulose-coated Fe3O4 nanoparticles by co-precipitation method. Moreover, the glucose oxidase (GOx, from Aspergillus niger) was efficiently immobilized by the ZIF-8@Cellu@Fe3O4 nanocarriers with enhanced catalytic activities. The enzyme loading was 94.26 mg/g and the enzyme activity recovery was more than 124.2%. This efficiently immobilized enzyme exhibits promising applications in biotechnology, diagnosis, biosensing, and biomedical devices. Conclusions: A new core-shell magnetic ZIF-8/cellulose nanocomposite (ZIF-8@Cellu@Fe3O4) was fabricated and structurally characterized. Glucose oxidase (GOx) was successfully immobilized by the biocompatible ZIF-8@Cellu@ Fe3O4 with high protein loading (94.26 mg/g) and enhanced relative activity recovery (124.2%).
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