Journal
TISSUE BARRIERS
Volume 5, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21688370.2017.1283386
Keywords
antimicrobial peptides; cysteine proteases; entamoeba histolytica; epithelium; inflammasome; mucus; tight junction proteins
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Crohn's and Colitis Canada
- NSERC Alexander Graham Bell studentship
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Crohn's and Colitis Canada
- NSERC Alexander Graham Bell studentship
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Entamoeba histolytica (Eh) is the protozoan parasite responsible for intestinal amebiasis and interacts dynamically with the host intestinal epithelium during disease pathogenesis. A multifaceted pathogenesis profile accounts for why 90% of individuals infected with Eh are largely asymptomatic. For 100 millions individuals that are infected each year, key interactions within the intestinal mucosa dictate disease susceptibility. The ability for Eh to induce amebic colitis and disseminate into extraintestinal organs depends on the parasite competing with indigenous bacteria and overcoming the mucus barrier, binding to host cells inducing their cell death, invasion through the mucosa and outsmarting the immune system. In this review we summarize how Eh interacts with the intestinal epithelium and subverts host defense mechanisms in disease pathogenesis.
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