Journal
ANNUAL REVIEW OF PSYCHOLOGY, VOL 68
Volume 68, Issue -, Pages 517-544Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-psych-010416-044208
Keywords
childhood trauma; maltreatment; psychopathology; psychiatric disorders; inflammation; immunity
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Childhood trauma is a key risk factor for psychopathology. However, little is known about how exposure to childhood trauma is translated into biological risk for psychopathology. Observational human studies and experimental animal models suggest that childhood exposure to stress can trigger an enduring systemic inflammatory response not unlike the bodily response to physical injury. In turn, these hidden wounds of childhood trauma can affect brain development, key behavioral domains (e. g., cognition, positive valence systems, negative valence systems), reactivity to subsequent stressors, and, ultimately, risk for psychopathology. Further research is needed to better characterize the inflammatory links between childhood trauma and psychopathology. Detecting and healing these hidden wounds may help prevent and treat psychopathology emerging after childhood trauma.
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