Journal
CORTEX
Volume 86, Issue -, Pages 33-44Publisher
ELSEVIER MASSON
DOI: 10.1016/j.cortex.2016.09.016
Keywords
Memory; Hypoxia-ischaemia; Hippocampus; Thalamus; Mammillary bodies
Funding
- Medical Research Council [G03000117/65439, G1002276-E01/1]
- Intramural Research Program of the National Institute of Mental Health, National Institutes of Health
- National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London
- Medical Research Council [G0300117, G1002276] Funding Source: researchfish
- MRC [G0300117, G1002276] Funding Source: UKRI
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Developmental amnesia (DA) is a selective episodic memory disorder associated with hypoxia-induced bilateral hippocampal atrophy of early onset. Despite the systemic impact of hypoxia-ischaemia, the resulting brain damage was previously reported to be largely limited to the hippocampus. However, the thalamus and the mammillary bodies are parts of the hippocampal-diencephalic network and are, therefore also at risk of injury following hypoxic-ischaemic events. Here, we report a neuroimaging investigation of diencephalic damage in a group of 18 patients with DA (age range 11-35 years), and an equal number of controls. Importantly, we uncovered a marked degree of atrophy in the mammillary bodies in two thirds of our patients. In addition, as a group, patients had mildly reduced thalamic volumes. The size of the anterior-mid thalamic (AMT) segment was correlated with patients' visual memory performance. Thus, in addition to the hippocampus, the diencephalic structures also appear to play a role in the patients' memory deficit. (C) 2016 The Authors. Published by Elsevier Ltd.
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