Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2017.00059
Keywords
Dishevelled; Wnt signaling; vertebrate embryonic development; embryonic expression; autosomal dominant robinow syndrome
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Funding
- German Research foundation (DFG) [SCHA965/6-1, 6-2]
- Max Planck Society (MPG)
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Dishevelled (DVL) proteins are highly conserved in the animal kingdom and are important key players in beta-Catenin-dependent and -independent Wnt signaling pathways. Vertebrate genomes typically comprise three DVL genes, DVL1, DVL2, and DVL3. Expression patterns and developmental functions of the three vertebrate DVL proteins however, are only partially redundant in any given species. Moreover, expression and function of DVL isoforms have diverged between different vertebrate species. All DVL proteins share basic functionality in Wnt signal transduction. Additional, paralog-specific interactions and functions combined with context-dependent availability of DVL isoforms may play a central role in defining Wnt signaling specificity and add selectivity toward distinct downstream pathways. In this review, we recapitulate briefly cellular functions of DVL paralogs, their role in vertebrate embryonic development and congenital disease.
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