Journal
JOURNAL OF DIABETES RESEARCH
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/9850398
Keywords
-
Funding
- Medical University of Bialystok, Poland [N/ST/MN/17/001/1118, N/ST/ZB/17/003/1109, N/ST/ZB/17/004/1109]
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Before this study, there had been no research evaluating the relationship between a lysosomal exoglycosidase profile and secretory function in the salivary glands of rats with streptozotocin-(STZ-) induced type 1 diabetes. In our work, rats were divided into 4 groups of 8 animals each: control groups (C2, C4) and diabetic groups (STZ2, STZ4). The secretory function of salivary glands-nonstimulated and stimulated salivary flow, a-amylase, total protein-and salivary exoglycosidase activities-N-acetyl-beta-hexosaminidase (HEX, HEX A, and HEX B), beta-glucuronidase, alpha-fucosidase, beta-galactosidase, and alpha-mannosidase-was estimated both in the parotid and submandibular glands of STZ-diabetic and control rats. The study has demonstrated that the activity of most salivary exoglycosidases is significantly higher in the parotid and submandibular glands of STZ-diabetic rats as compared to the healthy controls and that it increases as the disease progresses. Reduced secretory function of diabetic salivary glands was also observed. A significant inverse correlation between HEX B, alpha-amylase activity, and stimulated salivary flow in diabetic parotid gland has also been shown. Summarizing, STZ-induced diabetes leads to a change in the lysosomal exoglycosidase profile and reduced function of the salivary glands.
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