Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA
Volume 7, Issue 3, Pages 374-385Publisher
KARGER
DOI: 10.1159/000481853
Keywords
Delirium; S100B; Cerebrospinal fluid; Phosphorylated tau; Hip fracture
Categories
Funding
- Research Council of Norway through the program Improving mental health of older people through multidisciplinary efforts [187980/H10]
- Oslo University Hospital
- Sophies Minde Foundation
- Norwegian Health Association [1513]
- Norwegian Association for Public Health
- Civitan's Research Foundation
- Medical Student Research Program at the University of Oslo
- Swedish Research Council
- Swedish Alzheimer Foundation
- Swedish Brain Foundation
- Torsten Soderberg Foundation
- South-Eastern Norway Regional Health Authority
Ask authors/readers for more resources
Objectives: This study aimed to investigate the relationship between cerebrospinal fluid (CSF) S100B astrocyte-derived protein and delirium and to perform stratified analyses according to clinical and CSF markers of dementia. Methods: We performed a prospective cohort study in a university hospital setting. The participants were patients admitted for hip fracture (n = 98) or for elective surgery (n = 50). Delirium was assessed daily perioperatively in hip fracture patients using the Confusion Assessment Method. A consensus-based diagnosis of prefracture dementia was made using all available information. CSF was drawn at the onset of spinal anesthesia. S100B and phosphorylated tau (P-tau) concentrations were measured using electro-chemiluminescence immunoassay and enzyme-linked immunosorbent assays, respectively. Results: In the hip fracture population (n = 98) there was no significant difference in CSF S100B concentrations between patients with ongoing preoperative (i.e., prevalent) delirium (n = 36, median [interquartile range] 1.11 mu g/L [0.91-1.29]) and patients who never developed delirium (n = 46, 1.08 mu g/L [0.92-1.28], p = 0.92). In patients without preoperative delirium, those who developed delirium postoperatively (i.e., incident delirium) (n = 16, 1.38 mu g/L [1.08-1.62]) had higher concentrations of S100B than the 46 who never did (p = 0.013). This difference was confined to patients with pathological concentrations of P-tau (= 60 ng/L, n = 38). We also found that P-tau and S100B were correlated in CSF in the elective surgery patients. Conclusions: CSF S100B was elevated in patients with incident delirium who also had pathological levels of the Alzheimer disease biomarker P-tau, suggesting vulnerability caused by a preexisting process of astrocytic activation and tau pathology. (c) 2017 The Author(s) Published by S. Karger AG, Basel.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available