Journal
JOURNAL OF CANCER
Volume 8, Issue 19, Pages 4106-4116Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.21024
Keywords
lncRNA XIST; miR-429; glioma; HBMVECs; angiogenesis
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Funding
- research fund for National Natural Science Foundation of China [81602624]
- Project of Science and Technology Department of Zhejiang Province [2015C37012]
- Science and Technology Creative Activity Plan for University Students in Zhejiang Province [2016R410037]
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Glioma is a worldwide malignancy, which displays significantly active metastasis and angiogenesis. Interaction between long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) has been shown to play crucial role in regulating tumor properties. However, the potential of lncRNA X-inactive specific transcript (XIST) to function as a miRNA regulator and its relevance in glioma tumorigenicity and angiogenesis have so far remained unclear. Expression analysis of lncRNA XIST in glioma cells revealed its significant up-regulation. Interestingly, silencing of XIST repressed both metastatic and pro-angiogenic ability in vitro as well as in vivo. Subsequent studies revealed that lncRNA XIST expression inversely correlated with miR-429 expression in glioma cells; miR-429 modulated XIST expression by directly targeting the XIST gene sequence. In addition, miR-429 inhibitor restored metastatic and pro-angiogenic ability of gliomas abolished by silencing XIST. Our data provide insight into the key roles of the lncRNA-miRNA functional network in gliomas, which can aid in developing new therapeutic strategies for gliomas through clinical trials.
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