Journal
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Volume 6, Issue 4, Pages -Publisher
WILEY
DOI: 10.1161/JAHA.116.003918
Keywords
autologous stem cell-sheet; cellular transplantation e; jection fraction; growth factors and cytokines; ischemic cardiomyopathy; myocardial regeneration
Categories
Funding
- Research on Regenerative Medicine for Clinical Application of Health and Labour Sciences Research Grant in Japan
- Japan Agency for Medical Research and Development (AMED) Grant in Japan
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Background-When transplanted into failing heart, autologous somatic tissue-derived cells yield functional recovery via paracrine effects that enhance native regeneration. However, the therapeutic effects are modest. We developed a method in which scaffold-free cell sheets are attached to the epicardial surface to maximize paracrine effects. This Phase I clinical trial tested whether transplanting autologous cell-sheets derived from skeletal muscle is feasible, safe, and effective for treating severe congestive heart failure. Methods and Results-Fifteen ischemic cardiomyopathy patients and 12 patients with dilated cardiomyopathy, who were in New York Heart Association functional class II or II and had been treated with the maximum medical and/or interventional therapies available, were enrolled. Scaffold-free cell sheets of 3 to 9 x 108 cells derived from autologous muscle were transplanted over the LV free wall via left thoracotomy, without additional interventional treatments. There were no procedure-related major complications during follow-up. The majority of the ischemic cardiomyopathy patients showed marked symptomatic improvement in New York Heart Association classification (pre: 2.9 +/- 0.5 versus 6 months: 2.1 +/- 0.4, P<0.01; 1 year: 1.9 +/- 0.3, P<0.01) and the Six-Minute Walk Test with significant reduction of serum brain natriuretic peptide level (pre: 308 +/- 72 pg/mL versus 6 months: 191 +/- 56 versus 1 year: 182+46, P<0.05), pulmonary artery pressure, pulmonary capillary wedge pressure, pulmonary vein resistance, and left ventricular wall stress after transplantation instead of limited efficacy in dilated cardiomyopathy patients. Conclusions-Cell-sheet transplantation as a sole therapy was feasible for treating cardiomyopathy. Promising results in the safety and functional recovery warrant further clinical follow-up and larger studies to confirm this treatment's efficacy for severe congestive heart failure.
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