Journal
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Volume 6, Issue 7, Pages -Publisher
WILEY
DOI: 10.1161/JAHA.116.005025
Keywords
cardiovascular disease risk factors; cytomegalovirus; infectious disease; meta-analysis; prospective cohort study; virus
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Background-Several studies have suggested that cytomegalovirus infection is likely associated with an increased relative risk of cardiovascular disease (CVD); however, the results are inconsistent. We aimed to provide a systematic review and meta-analysis of community-based prospective studies assessing the association between cytomegalovirus infection and relative risk of CVD. Methods and Results-We searched Medline and EMBASE to retrieve prospective studies that reported risk estimates of the association between cytomegalovirus infection and relative risk of CVD. The search yielded 10 articles including a total of 34 564 participants and 4789 CVD patients. Overall, exposure to cytomegalovirus infection was associated with a 22% (relative risk: 1.22, 95% CI: 1.07-1.38, P=0.002) increased relative risk of future CVD. We estimated that 13.4% of CVD incidence could be attributable to cytomegalovirus infection. Conclusions-In conclusion, cytomegalovirus infection is associated with a significantly increased relative risk of CVD.
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