Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 67, Issue 1, Pages 1-10Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2017.1291516
Keywords
Anticancer activity; chitosan; cytotoxicity; green synthesis; silver nanocomposites
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Funding
- Ministry of Education, Youth and Sports of the Czech Republic - NPU Program I [LO1504]
- Slovak Grant Agency VEGA [2/0156/15]
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Chitosan-silver nanocomposites (CS-HDA-AgNCs) was prepared using chitosan, biogenic silver nanocomposites, and crosslinker, hexamethylene 1,6-di(amino carboxysulfonate) (HDA). The film is flexible and transparent. Its physical, mechanical, thermal, hydrophilicity, and swelling properties were improved by HDA (2.5%). The antimicrobial activity of CS-HDA-AgNCs were not displayed any remarkable zone of inhibition but showed toxic effect in the presence of normal 3T3 fibroblasts and cancer HeLa cells. It decreases to ca. 5-7% for both cell lines. In conclusion, it can be mentioned that the CS-HDA-AgNCs, a kind of new functional biomaterial, could be useful for health-care applications. [GRAPHICS]
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