Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 67, Issue 3, Pages 161-173Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2017.1309543
Keywords
Biodegradable materials; capacitively coupled radio frequency plasma; control release; diffuse coplanar surface barrier discharge; plasma treatments
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Funding
- Czech Science Foundation [15-08287Y]
- Ministry of Agriculture of the Czech Republic [QJ1310254]
- Ministry of Education, Youth and Sports of the Czech Republic [LO1504, CZ.1.05/2.1.00/19.0409]
- Ministry of Education, Science, Research and Sports of the Slovak Republic
- Slovak Academy of Sciences, as a part of the VEGA project [02/0199/14]
- Slovak Research and Development Agency [APVV-14-0518]
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Investigation was made into the effect of plasma treatment on the release kinetics of the drug Temozolomide (TMZ) from thin, biodegradable polyester films, comprising polylactic acid (PLA) and polyester urethane. The authors utilized two systems to achieve this, the first being diffuse coplanar surface barrier discharge, applying air as the gaseous medium, while the other involved capacitively coupled radio frequency discharge plasma under an argon atmosphere with hexamethyldisiloxane. Results showed that both forms of plasma treatment positively reduced the undesirable burst effect and benefited the release rate of TMZ. The hydrolytic degradability of the materials was slightly enhanced following hydrophilization, whereas the same diminished after hydrophobization had taken place. This was especially true for PLA due to modification of its wettability.
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