Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 66, Issue 14, Pages 742-747Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1263956
Keywords
Characterization; hydrophobic modified alginate; micelles; orthogonal optimization; synthesis
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Funding
- National Natural Science Foundation of China [20876081]
- Natural Science Foundation of Shandong Province [ZR2012BM015]
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Hydrophobic modified alginate (HM-alginate) has been synthesized by derivatization of sodium alginate (SA) with dodecyl glycidyl ether (DGE) in an aqueous solution. Using orthogonal optimization methods, the optimum combined parameters were explored as follows: 75 degrees C, 70mL H2O, 0.20mmol sodium dodecyl sulfate and 2.0mL DGE (mole ratio of SA to DGE, 2.2:1), the maximum yield was 112.62%. Their micellar properties and rheological properties were investigated, respectively. In addition, their drug delivery behaviors were evaluated with Sudan IV as a hydrophobic model drug.
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