Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1862, Issue 1, Pages 69-80Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2016.07.010
Keywords
ERMES complex; vCLAMP; Mitochondria; Phospholipids; Contact sites
Funding
- Deutsche Forschungsgemeinschaft [DI 1386/2-1, DR 1028/7-1]
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Mitochondria are unique organelles that contain their own - although strongly reduced - genome, and are surrounded by two membranes. While most cellular phospholipid biosynthesis takes place in the ER, mitochondria harbor the whole spectrum of glycerophospholipids common to biological membranes. Mitochondria also contribute to overall phospholipid biosynthesis in cells by producing phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. Considering these features, it is not surprising that mitochondria maintain highly active exchange of phospholipids with other cellular compartments. In this contribution we describe the transport of phospholipids between mitochondria and other organelles, and discuss recent developments in our understanding of the molecular functions of the protein complexes that mediate these processes. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum. (C) 2016 Elsevier B.V. All rights reserved.
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