4.7 Article

An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 3, Pages 525-528

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc08971b

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Funding

  1. National Creative Research Initiative Program of the National Research Foundation of Korea (NRF) - Korean government (MSIP) [2012R1A3A2048814]
  2. National Research Foundation of Korea (NRF) - Korean government (MSIP) [2016R1E1A1A02920873]
  3. National Research Council of Science and Technology through the Degree & Research Center Program [DRC-14-1-KBSI]
  4. National Research Foundation of Korea [2016R1E1A1A02920873] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. The probe, TPQ, which displays high selectivity and anti-interference ability, was successfully applied to endogenous hNQO1 imaging and for the identification of different cancer cells.

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