Journal
ARCHIVES OF ORAL BIOLOGY
Volume 73, Issue -, Pages 105-112Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2016.09.012
Keywords
Head and neck squamous cell carcinoma; TP53; MicroRNA-18; Proliferation and migration; beta-TrCP2
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Funding
- Development of Science and Technology Projects in Yantai [2013WS203]
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Objective: To investigate the functional mechanism of microRNA-182 (miR-182) in head and neck squamous cell carcinoma (HNSCC). Design: HNSCC and normal samples were used to check both p53 and miR-182 expression. Two cancer cell lines with overexpression of miR-182 were used to check cell proliferation and migration. In vivo role of miR-182 was assessed using mouse xenograft tumor model. beta-TrCP2 was found to be direct target of miR-182 by luciferase reporter assay. Results: Overexpression of miR-182 was closely related with overproduction of p53 in HNSCC. Overexpression of miR-182 promoted cell proliferation and migration and its oncogenic effect was also confirmed in vivo. beta-TrCP2 acted as direct target of miR-182 and its overexpression can reverse the miR-182 induced cell proliferation and migration. Conclusion: Overexpression of TP53 mutation-associated miR-182 may promote tumor cell proliferation and migration in HNSCC and suggest possible biomarker for the prediction of tumor recurrence. (C) 2016 Elsevier Ltd. All rights reserved.
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