4.7 Article

Precipitation SELEX: identification of DNA aptamers for calcium phosphate materials synthesis

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 6, Pages 1092-1095

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc08687j

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Funding

  1. Emmanuel College
  2. NSF [DMR 1306117]
  3. Direct For Mathematical & Physical Scien
  4. Division Of Materials Research [1306117] Funding Source: National Science Foundation

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DNA aptamers that enhance calcium phosphate mineral formation were identified using a novel precipitation SELEX method. The evolved DNA library was substantially enriched in G nucleotides and in predicted G-quadruplex structures, suggesting their importance in the mechanism of mineralization. This work could readily be extended to provide additional novel DNA aptamers for materials synthesis.

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