Journal
CLINICS IN LIVER DISEASE
Volume 21, Issue 1, Pages 35-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2016.08.002
Keywords
Hepatotoxicity; Reactive metabolites; Mitochondria; Hepatocellular; Cholestasis
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Drug-induced hepatotoxicity (DIH) is a significant cause of acute liver failure and liver transplantation. Diagnosis is challenging due to the idiosyncratic nature, its presentation in the form of other liver disease, and the lack of a definite diagnostic criteria. Generation of reactive metabolites, oxidative stress, and mitochondria! dysfunction are common mechanisms involved in DIH. Certain risk factors associated with a drug and within an individual further predispose patients to DIH.
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