Journal
BIOMATERIALS
Volume 115, Issue -, Pages 81-89Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.11.020
Keywords
Dendritic cells; Immunology; Adjuvants; Nanomedicine; DNA nanotechnology
Funding
- Research Fund for International Young Scientists from National Natural Science Foundation of China [81550110507]
- National Research Foundation of Korea (NRF) grant by Korea government (MSIP) [2014-R1A2A2A04002526]
- Pioneer Research Center Program through NRF - Ministry of Science, ICT & Future Planning [2014M3C1A3054141]
- NRF grant by Ministry of Education [NRF-2014R1A1A2059063]
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We introduce a versatile carrier system for in vitro and in vivo immune stimulation based on soft matter DNA nanoparticles (NPs). The incorporation of lipid-modified nucleotides into DNA strands enables the formation of micelles of uniform size. In a single self-assembly step, the micelles can be equipped with immune adjuvant (CpG) motifs and fluorescent probes. The immunological effects of CpG confined at the NP surface were studied in a comprehensive manner in animal experiments. Dose-dependent activation of spleen dendritic cells (DCs) by CpG-conjugated NP was observed, which was accompanied by the pronounced up-regulation of co-stimulatory molecule and cytokine production. (C) 2016 Elsevier Ltd. All rights reserved.
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