Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 3, Pages 2023-2028Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b14132
Keywords
self-assembly; protein-polymer conjugates; nanovesicles; protein delivery atom transfer radical polymeriiation
Funding
- National Natural Science Foundation of China [21274043, 21534006]
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We report a new and general method, in situ growth, for designing self-assembled protein polymer nano vesicles for intracellular protein delivery.In situ polymerization of a water-soluble monomer from a protein attached with a polymerization initiator yields amphiphilic protein conjugates of a water-insoluble polymer. These conjugates can in situ self assemble into nanostructures with tunable morphologies from spheres to vesicles. Interestingly, an exogenous protein can be in situ encapsulated inside protein-polymr nanovesicles for enhanced intracellular protein delivery: The in situ growth method may open up new opportunities for designing a variety of self-assembled protein-polymer nanostructures tailored to specific applications.
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