Journal
BRITISH JOURNAL OF CANCER
Volume 116, Issue 3, Pages 405-413Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2016.425
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Funding
- Cancer Research UK
- National Institute for Health Research (NIHR) Health Technology Assessment (HTA)
- PHARMO Institute for Drug Outcomes Research
- Cancer Research UK [15015] Funding Source: researchfish
- Medical Research Council [MC_UU_12023/28] Funding Source: researchfish
- National Institute for Health Research [12/01/38] Funding Source: researchfish
- MRC [MC_UU_12023/28] Funding Source: UKRI
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Background: Previous studies suggested a relationship between aspirin use and mortality reduction. The mechanism for the effect of aspirin on cancer outcomes remains unclear. The aim of this study was to evaluate aspirin use and survival in patients with gastrointestinal tract cancer. Methods: Patients with gastrointestinal tract cancer diagnosed between 1998 and 2011 were included. The population-based Eindhoven Cancer Registry was linked to drug-dispensing data from the PHARMO Database Network. The association between aspirin use after diagnosis and overall survival was analysed using Cox regression models. Results: In total, 13 715 patients were diagnosed with gastrointestinal cancer. A total of 1008 patients were identified as aspirin users, and 8278 patients were identified as nonusers. The adjusted hazard ratio for aspirin users vs nonusers was 0.52 (95% CI 0.44-0.63). A significant association between aspirin use and survival was observed for patients with oesophageal, hepatobiliary and colorectal cancer. Conclusions: Post-diagnosis use of aspirin in patients with gastrointestinal tract malignancies is associated with increased survival in cancers with different sites of origin and biology. This adds weight to the hypothesis that the anti-cancer effects of aspirin are not tumour-site specific and may be modulated through the tumour micro-environment.
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