Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 44, Issue -, Pages 86-92Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2016.09.004
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Funding
- ARC Centre of Excellence in Advanced Molecular Imaging [CE140100011]
- National Health and Medical Research Council of Australia [1059278, 1037320]
- National Health and Medical Research Council of Australia [1059278] Funding Source: NHMRC
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Due to recent technical developments in microscopy, huge advances have been made in our understanding of the architecture of the cell membrane. It is now well appreciated that nanoscale clustering is a common feature of membrane proteins. Many of these clusters have been implicated in signal initiation and integration platforms. However, the mechanisms that mediate the dynamic nanoscale arrangement of membrane proteins are not fully understood and could involve lipid domains, electrostatic interactions between proteins and lipid, protein scaffolding as well as purely mechanical processes. In this review we summarise these mechanisms giving rise to dynamic nanoscale protein reorganisation in the plasma membrane with reference to recent examples of immune receptor clustering to illustrate general principles.
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