Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 4, Pages 3885-3894Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b13176
Keywords
hierarchical nanostructures; polyelectrolyte complexation; nanoconfinement; miniemulsion; protein drug delivery; glycol chitosan; interfacial cross-linking
Funding
- BMBF [01KX1237A]
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Peptide drugs delivered orally need to be protected from degradation for achieving their functions. To fulfill the complicated task of oral drug delivery, we present a hierarchically structured drug-delivery system that can undertake structural changes, so multiple functions can be triggered by a sequence of stimuli. Such hierarchical system is achieved in a nanoparticle-in-nanofiber configuration, in which both the nanofibers and the nanoparticles are pH-responsive and biocompatible. A model peptide is efficiently encapsulated under mild condition, and the nanocarriers are further electrospun with a pH-responsive mucoadhesive polymer. The nanoparticles are released from the nanofibers, and thereafter the peptides are released from the nanoparticles in a pH-responsive manner. The nanoparticles are compatible with caco-2 cells, and the endocytosis of the nanoparticles is described in detail.
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