Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 42, Issue -, Pages 6-14Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2016.10.002
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Funding
- Italian Ministry of Education [PRIN 2010HXAW77]
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Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues that could be tackled with either or both approaches are finally pointed out.
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