Journal
DRUG DISCOVERY TODAY
Volume 22, Issue 2, Pages 327-339Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.10.011
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Funding
- World Animal Protection
- European Community's Seventh Framework Programme (FP7) [267038]
- Cosmetics Europe
- NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton NHS Foundation Trust
- Imperial College London
- MRC [MC_PC_15031, G0900536, G1001367] Funding Source: UKRI
- Medical Research Council [G1001367, G1000758] Funding Source: researchfish
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Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non -governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.
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