Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 110, Issue -, Pages 80-101Publisher
ELSEVIER
DOI: 10.1016/j.addr.2016.08.005
Keywords
Nanoparticles; Targeted drug delivery; Targeted gene delivery; Liposomes; CPP; PEG; Stimuli-responsive
Categories
Funding
- [NSF/CBET-1403564]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1403564] Funding Source: National Science Foundation
Ask authors/readers for more resources
Liposomal nanomedicine has led to clinically useful cancer therapeutics like Doxil and DaunoXome. In addition, peptide-functionalized liposomes represent an effective drug and gene delivery vehicle with increased cancer cell specificity, enhanced tumor-penetrating ability and high tumor growth inhibition. The goal of this article is to review the recently published literature of the peptide-amphiphiles that were used to functionalize liposomes, to highlight successful designs that improved drug and gene delivery to cancer cells in vitro, and cancer tumors in vivo, and to discuss the current challenges of designing these peptide-decorated liposomes for effective cancer treatment. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available