Journal
BIOMATERIALS
Volume 116, Issue -, Pages 1-9Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.11.045
Keywords
Subcutaneous abscesses; Photothermal therapy; pH-responsive nanoparticles; Charge conversion; Imaging guiding
Funding
- Ministry of Science and Technology of Taiwan (ROC) [MOST 103-2221-E-007-022-MY3]
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Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that Is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood. The local temperature of the NIR-irradiated PANI-GCS NPs is estimated to be approximately 5 degrees C higher than their ambient tissue temperature, ensuring specific and direct heating of their aggregated bacteria; hence, damage to tissue is reduced and wound healing is accelerated. The above results demonstrate that PANI-GCS NPs are practical for use in the photothermal ablation of focal infections. (C) 2016 Elsevier Ltd. All rights reserved.
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