Journal
CLINICS IN LIVER DISEASE
Volume 21, Issue 1, Pages 1-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2016.08.001
Keywords
Drug metabolism; Cytochrome P450; Conjugation; Drug transporters; Liver metabolism; Phase I, II and III metabolism enzyme
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Metabolism is a biotransformation process, where endogenous and exogenous compounds are converted to more polar products to facilitate their elimination from the body. The process of metabolism is divided into 3 phases. Phase I metabolism involves functionalization reactions. Phase II drug metabolism is a conjugation reaction. Phase III refers to transporter-mediated elimination of drug and/or metabolites from body normally via liver, gut, kidney, or lung. This review presents basic information on drug-metabolizing enzymes and potential factors that might affect the metabolic capacities of the enzyme or alter drug response or drug mediated toxicities.
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