Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 27, Issue 3, Pages 670-674Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.11.044
Keywords
Callicarpa kwangtungensis; 9,10-seco-Abietane diterpenoid; NO inhibitory activities; iNOS; Molecular docking; Terpenoids
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Funding
- National Natural Science Foundation of China [21372125]
- Natural Science Foundation of Tianjin, China [16JCYBJC27700]
- State Key Laboratory of Medicinal Chemical Biology [201602007]
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A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2-13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein. (C) 2016 Elsevier Ltd. All rights reserved.
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