Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 35, Issue -, Pages 8-15Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2016.10.003
Keywords
-
Categories
Funding
- Abisch Frenkel Foundation for the Promotion of Life Sciences
- Gurwin Family Fund for Scientific Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Crown Endowment Fund for Immunological Research
- estate of Jack Gitlitz
- estate of Lydia Hershkovich
- Benoziyo Endowment Fund for the Advancement of Science
- Adelis Foundation
- John L. and Vera Schwartz, Pacific Palisades
- CNRS (Centre National de la Recherche Scientifique)
- estate of Samuel
- European Research Council
- Kenneth Rainin Foundation
- German-Israel Binational Foundation
- Israel Science Foundation
- Minerva Foundation
- Rising Tide Foundation
- Alon Foundation scholar award
Ask authors/readers for more resources
In the intestine, the microbial genomes and repertoire of biochemical reactions outnumber those of the host and significantly contribute to many aspects of the host's health, including metabolism, immunity, development and behavior, while microbial community imbalance is associated with disease. The crosstalk between the host and its microbiome occurs in part through the secretion of metabolites, which have a profound effect on host physiology. The immune system constantly scans the intestinal microenvironment for information regarding the metabolic state of the microbiota as well as the colonization status. Recent studies have uncovered a major role for microbial metabolites in the regulation of the immune system. In this review, we summarize the central findings of how microbiotamodulated metabolites control immune development and activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available