4.7 Article

Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties

Journal

BIOORGANIC & MEDICINAL CHEMISTRY
Volume 25, Issue 3, Pages 1153-1162

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.12.023

Keywords

Quinoline; Antifungal; Anticancer; Antioxidant; Calix[n]arenes

Funding

  1. Fundacao de Amparo a Pesquisa do Estado de Minas Gerais - Brazil (FAPEMIG)
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - Brazil (CNPq)
  3. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil (CAPES)
  4. Research Fellowships from CNPq
  5. National Program for Academic Cooperation (PROCAD) of CAPES/Brazil

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An efficient method for the synthesis of quinolines using microwave irradiation was developed providing 28 quinolines with good yields. The reaction procedures are environmentally friendly, convenient, mild and of easy work-up. Quinolines were evaluated for their antifungal, anticancer and antioxidant properties and exhibited high activities in all tests performed. (C) 2016 Elsevier Ltd. All rights reserved.

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