Journal
CARDIOVASCULAR DRUGS AND THERAPY
Volume 31, Issue 1, Pages 63-75Publisher
SPRINGER
DOI: 10.1007/s10557-016-6711-0
Keywords
Cancer; anthracycline; doxorubicin; chemotherapy; cardiotoxicity; cardioprotection
Funding
- Biomedical Research Centre [BRC233/CM/SD/101320]
- Department of Health's National Institute for Health Research Biomedical Research Centres
- National Institute for Health Research [ACF-2011-18-013] Funding Source: researchfish
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Anthracycline chemotherapy maintains a prominent role in treating many forms of cancer. Cardiotoxic side effects limit their dosing and improved cancer outcomes expose the cancer survivor to increased cardiovascular morbidity and mortality. The basic mechanisms of cardiotoxicity may involve direct pathways for reactive oxygen species generation and topoisomerase 2 as well as other indirect pathways. Cardioprotective treatments are few and those that have been examined include renin angiotensin system blockade, beta blockers, or the iron chelator dexrazoxane. New treatments exploiting the ErbB or other novel pro- survival pathways, such as conditioning, are on the cardioprotection horizon. Even in the forthcoming era of targeted cancer therapies, the substantial proportion of today's anthracycline- treated cancer patients may become tomorrow's cardiac patient.
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