Journal
DRUG DISCOVERY TODAY
Volume 22, Issue 2, Pages 282-298Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.09.016
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Funding
- National Research Foundation of Korea (NRF)-Ministry of Education, Science and Technology [20090093815]
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Melanin, primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a process called melanogenesis. However, the abnormal accumulation of melanin causes dermatological problems such as cafe-au-lait macules ephelides (freckles), solar lentigo (age spots) and melasma, as well as cancer and vitiligo. Hence the regulation of melanogenesis is very important for treating hyperpigmentary disorders. Numerous antimelanogenic agents that target tyrosinase activity and/or stability, melanosome maturation, transfer and trafficking, or melanogenesis-related signaling pathways have been developed. This article reviews recent advances in research and development of human tyrosinase and melanogenesis-related signaling pathway inhibitors. Attempts have been made to provide a complete description of the mechanism of action of inhibitors on various melanogenesis signaling pathways.
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