Journal
BIOMACROMOLECULES
Volume 18, Issue 2, Pages 483-489Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.6b01563
Keywords
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Funding
- Center for Cancer Nanotechnology Excellence initiative of the National Cancer Institute of the National Institutes of Health [U54CA151880, U54CA199091]
- AFOSR [FA9550-12-1-0280]
- NTU-NU Institute for NanoMedicine located at the International Institute for Nanotechnology, Northwestern University
- Nanyang Technological University, Singapore
- NSF-NSEC [NSF EEC-0647560]
- NIH-CCNE
- NSF-MRSEC [NSF DMR-1121262]
- Keck Foundation
- State of Illinois
- Northwestern University
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Small-sized (similar to 65 nm) doxorubicin (Dox)-loaded polymeric nanoparticles (PNPs) were modified with oligonucleotides to form colloidally stable Dox-loaded polymeric spherical nucleic acid (Dox-PSNA) nanostructures in biological media. The nucleic acid shell facilitates the cellular uptake of Dox-PSNA, which results in in vitro cytotoxicity against SKOV3 cancer cells.
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